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Cyclobenzaprine: Uses, Interactions, Mechanism of Action DrugBank Online

Cyclobenzaprine: Uses, Interactions, Mechanism of Action DrugBank Online

The half-life of a drug describes how long it takes for half of a single dose to be removed from your system. Because the drugs have different mechanisms of action, they sometimes may be prescribed in combination. However, only a physician can make these drugs safely available to anyone in combination.

It works by blocking pain sensations that are sent to your brain. How cyclobenzaprine (Flexeril) works is not well understood, but it helps alleviate stiffness, pain, and discomfort due to sprains, strains, or injuries to muscles. It is also sometimes prescribed off-label to treat fibromyalgia pain. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Flexeril only for the indication prescribed.

Cyclobenzaprine’s Effectiveness Timeframe

It may also be used when in situations where the effects of a specific drug combination are desired or if the combination’s positive effects outweigh the adverse effects one may experience. When an individual is taking drugs with major drug-drug interactions, they must be closely monitored. The use of weed or marijuana while on Cyclobenzaprine treatment is another of the drugs that interact moderately with Cyclobenzaprine.

View interaction reports for Flexeril (cyclobenzaprine) and the medicines listed below. The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache.

Cyclobenzaprine Oral: Uses, Side Effects, Interactions, Pictures … – WebMD

Cyclobenzaprine Oral: Uses, Side Effects, Interactions, Pictures ….

Posted: Mon, 25 Aug 2014 23:08:32 GMT [source]

Based on the findings, FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies can you take flexeril and percocet together indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment.

If you suspect someone has taken too much cyclobenzaprine, call 911. A cyclobenzaprine overdose can be fatal, especially if the drug is taken with alcohol. Whenever someone is using a benzodiazepine, their physician should monitor them closely and pay attention to any other drugs they are prescribed or using.

Drugs & Vitamins

If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Examples of drugs that can cause interactions with cyclobenzaprine are listed below. Cyclobenzaprine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

Using both Cyclobenzaprine and weed together can have a wide range of adverse effects. It is advised not to use the two together as it can increase the risk of side effects such as confusion, trouble concentrating, dizziness, and drowsiness. Some individuals, especially the elderly, may also experience impaired judgment, thinking, and poor motor coordination. It is highly recommended not to use weed while on Flexeril, especially when doing anything requiring focus and mental alertness, such as driving motor vehicles or operating heavy machinery. Mixing alcohol with Flexeril may worsen its side effects and cause new symptoms to arise, so taking the two together is not recommended and must be resisted. Flexeril and alcohol are both central nervous system (CNS) depressants, with each of them having its own effective means of relaxing or easing the pain.

  • Cyclobenzaprine warnings, comprising the effects of using each of these medications on their own include a slowing of the mental faculties, drowsiness, lightheadedness, and lowered motor coordination.
  • When taken at higher doses, such as 30 to 50 mg, individuals have said that they feel as if they are floating outside their own bodies.
  • Because of the possibility of higher blood levels in the elderly as compared to younger adults, use of cyclobenzaprine extended-release capsules is not recommended in the elderly.
  • Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. Other drugs may interact with cyclobenzaprine, including prescription and over-the-counter medicines, vitamins, and herbal products. Cyclobenzaprine is a prescription medicine to treat muscle spasms like Charley horses which may be caused by poor blood flow, dehydration, or lack of potassium or magnesium in the diet. There are other causes of spasms, but these are common reasons why muscles tend to tighten. Cyclobenzaprine is typically taken when a person is told to rest or participate in physical therapy, helping to relax the tension in the muscles. You’ll find cyclobenzaprine in brand-name medications such as Flexeril, Fexmid, and Amrix.

More common side effects

If they’re more severe or don’t go away, talk with your doctor or pharmacist. Some facilities also include step-down levels of care to include a partial hospitalization program or an intensive outpatient program. The costs and locations of these facilities can vary greatly, so speak with someone who can help you make a decision that is within your budget and that best suits your treatment needs. He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture. When it comes to the matter of drug interactions between Cyclobenzaprine and other drugs, there is a lot to look out for and factors to be considered.